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What is Azelaic Acid?

Meaning of Azelaic Acid

Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. It is saturated with dicarboxylic acid as a white powder .

It is found in wheat, rye and barley. It is a component of a number of hair and skin conditioners .

Azelaic acid is used to soothe and treat skin lesions, such as acne. Azelaic acid is in a class of medications called dicarboxylic acids .

It is indicated for acne because it kills the bacteria that infect the pores and decreases the production of keratin .

Azelaic acid is good, as it is one of the active substances best known for its effectiveness in treating mild and moderate acne.

In addition to other epidermal problems . Present in wheat, barley and rye, azelaic acid develops from the fermentation of these cereals by the fungus.

Like penicillin, which is also a substance produced by fungi, this acid has a bactericidal capacity that inhibits the development of bacteria in the hair follicle.

Additionally, Azelaic Acid also fights free radicals by preventing skin aging , reduces inflammation, and has the power to lighten blemishes.

It can also act as a 5-alpha-reductase enzyme reducer and treat hair loss.

Production

Azelaic acid is produced industrially by ozonolysis of oleic acid . The byproduct is nonanoic acid. It is produced naturally by Malassezia furfur (Pityrosporum ovale).

yeast that lives on the skin. Bacterial degradation of nonanoic acid produces azelaic acid.

biological function

In plants, azelaic acid serves as a ” distress reflex ” involved in defense responses after infection.

It serves as a signal that induces the accumulation of salicylic acid , an important component of the plant’s defense response.

Azelaic Acid Uses

Azelaic acid comes as a gel and a cream to rub on the skin . It is important to follow the instructions on the package or as prescribed by your doctor .

Azelaic acid controls acne , kills bacteria, and reduces inflammation and rosacea. Results are usually within 4 weeks or more, depending on the person and the case.

How to use the gel or cream:

  • Wash skin with mild soap and water and pat dry.
  • Ask your dermatologist for an alcohol-free cleanser.
  • Apply a thin layer on the skin.
  • Take care of your eyes and your mouth.

What are the side effects?

Certain symptoms may occur during treatment with azelaic acid , such as redness, burning. Tell your doctor about persistent symptoms.

Contraindications: hypersensitivity to propylene glycol.

Recommendation

Different forms of acne vulgaris, i.e. inflammatory and non-inflammatory forms.

Properties

It is an agent that acts on the cell’s mitochondria and has little or no effect on other skin cells or normal melanocytes.

It acts as a competitive inhibitor of tyrosinase “ in vitro ”. It is indicated for melasma, chloasma, acne, melanotic syndromes, hyperpigmentation.

Azelaic acid is an unbranched, saturated, dicarboxylic acid: 1,7-heptanedicarboxylic acid (nonanedioic acid).

The antibacterial effect is demonstrated by the decrease in bacterial colonization on the skin surface and within the follicle.

Reduction in the percentage of free fatty acids in lipids on the skin surface. It exerts a direct “ comedolytic ” effect on the efflorescences that influence the differentiation of keratinocytes and, possibly, their proliferation.

Allows normalization of altered follicular keratinization . Effective pharmacological action is based on its easy penetration into the skin.

As a small part of the topically applied acid is absorbed percutaneously, biotransformation and elimination should also be considered as pharmacokinetic parameters.

Under clinical conditions, including large-area application, generally no more than 6 g per day can be used.

Azelaic Acid Application

Polymers and related materials

Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine acid, azelaic acid forms Nylon -6.9, which finds specialized uses as plastic.

Skin

Azelaic acid is used to treat mild to moderate acne . It belongs to a class of medications called carboxylic acids.

It works by killing acne bacteria that infect the pores of the skin. In addition, it decreases the production of keratin, which is a natural substance that promotes the growth of bacteria.

Azelaic acid is also used as a topical gel for the treatment of rosacea , due to its ability to reduce inflammation.

Azelaic acid has been used to treat skin pigmentation, including melasma and post-inflammatory hyperpigmentation, particularly in people with darker skin types.

It has been recommended as an alternative to hydroquinone (HQ). As a tyrosinase inhibitor, azelaic acid reduces melanin synthesis.

Benefits of Azelaic Acid

  • Effective in treating acne.
  • It slows down the growth of bacteria in the hair follicle.
  • Delays premature aging of the skin.
  • Fight free radicals.
  • It stimulates hair growth.
  • Reduces inflammation and pigmentation.

Azelaic Acid Side Effects

At the start of administration, localized skin irritations may occur.

Other common side effects are: tingling, dry skin, and peeling.

Contact dermatitis and folliculitis are rare. In most cases, symptoms are mild and usually subside during treatment.

In rare cases, allergic skin reactions such as skin rash may occur. Before starting treatment with azelaic acid, consult your doctor and follow his recommendations.

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